Everything C. diff
This site is designed to be a resource for both practitioners and patients covering C. difficile core topics, recent manuscripts and conferences.
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Site Philosophy:
Practical up to date information about C. difficile infection for clinicians and patients. The patient section is geared to patients and explained in clear and understandable terms. The practitioner section provides evidenced based information for the practicing clinician. The goal of this site is to provide education through short videos with relevant clinical information for educational purposes.
Paul Feuerstadt MD, FACG, AGAF
Gastroenterology Center of Connecticut
2200 Whitney Avenue, Suite 360
Hamden, CT 06518
(203) 281-4463
@DrPaulGastro
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Short Biography
A native of Long Island, New York, Dr. Feuerstadt attended the University of Pennsylvania where he earned his Bachelor of Arts degree in Biology, with distinction in research and graduated Summa Cum Laude.
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Following completion of his undergraduate training, Dr. Feuerstadt attended the Weill Medical College of Cornell University in Manhattan, New York where he earned his Medical Doctor degree and stayed at New York Presbyterian Hospital/Weill Cornell medical center for his internship and residency in Internal Medicine. Following completion of his residency Dr. Feuerstadt then moved on to the Montefiore Medical Center in the Bronx, New York for his clinical fellowship training.
Throughout Dr. Feuerstadt’s training and practice he has been actively involved in research and other academic pursuits. His areas of interest include chronic diarrheal syndromes with a specific focus on Clostridioides difficile infection, irritable bowel syndrome (IBS) and ischemic diseases of the gut. He has presented his research extensively at national meetings and has authored and co-authored many manuscripts, textbook chapters and online modules. Another passion of Dr. Feuerstadt’s is teaching, frequently giving lectures locally, regionally and nationally and also mentoring the fellows in the Division of Digestive Disease at Yale-New Haven Hospital where he holds a clinical appointment as an Assistant Clinical Professor of Medicine.
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His clinical practice is his ultimate passion filling the majority of his work time as he sees a broad spectrum of patients with gastrointestinal and hepatic disease. Dr. Feuerstadt is an attending physician at the Gastroenterology Center of Connecticut and affiliated with the St. Raphael campus of Yale-New Haven Hospital, Yale-New Haven Hospital, and Milford Hospital.
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Financial Disclosures
Merck and Co.: Consultant and Speakers Bureau
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Ferring Pharmaceuticals Inc.: Consultant
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Roche Diagnostics Corporation: Consultant
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Premier Consulting Inc.:Consultant
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Brief Curriculum Vitae
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Education
Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York
Fellow in the Division of Gastroenterology, Completion: June 2010
American Board of Internal Medicine Certification: Gastroenterology
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New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York
Categorical Resident in the Department of Internal Medicine, Completion: June 2007
American Board of Internal Medicine Certification: Internal Medicine
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Weill Medical College of Cornell University, New York, New York
M.D. Degree, June 2004
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University of Pennsylvania, Philadelphia, Pennsylvania
Bachelor of Arts, Summa Cum Laude, May 2000
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Media
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Update of the 2019 C. difficile Literature Nov 19
Academy for Continued Healthcare Learning
The Emerging Role of the Gut Microbiome in Reducing Recurrence Oct 19
of C. difficile Infection
San Antonio, TX, American College of Gastroenterology Annual Meeting
Academy for Continued Healthcare Learning
Microbiota Restoration for Reduction of Recurrent C. difficile Infection - Oct 19
Understanding the Human Gut Microbiota
Washington DC, ID Week 2019
Academy for Continued Healthcare Learning
A Gut Check: Altering the GI Microbiome to Fight the C diff Invasion Aug 19
Audio Podcast, myCME
Optimal Strategies for Prevention and Treatment of C. difficile infection
A Gut Check: Altering the GI Microbiome to Fight the C diff Invasion—Case 2: A 77-Year-Old Male Patient With a History of Multiple Chronic Diseases Develops Diarrhea
Community and Healthcare Associated C. difficile Infection: Aug 19
Prevention and Management Across Points-of-Care
Case Presentation and Commentary, Academy for Continued Healthcare Learning
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C. difficile Infection and Recurrence: Targeting the Drivers of Pathogenesis: Oct 18
Restoring the Gut Microbiome and Approaches to Prevention of C. difficile
Infection and Recurrence
http://achlcme.org/digital/CDI181-03/Index.html
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C. difficile Spores and More Global Broadcasting Radio Network Jun 18
“C. difficile Infection Data; Digestive Disease Week 2018 & Current Clinical Trials”
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An Update on the 2017 IDSA/SHEA Clinical Practice Guidelines: Focus on the Mar 18
Identification and Treatment of Recurrent C. difficile
Interview, Academy for Continued Healthcare Learning
http://www.achlcme.org/CDI170-04
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Insights & Updates in Treatment of Iron Deficiency Anemia Jan 18
Video CME/Interview, Academy for Continued Healthcare Learning
https://learning.freecme.com/a/28499P37nRES
http://www.freecme.com/courses/2017/3/IDA170_ACHL
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Iron Deficiency Anemia in Inflammatory Bowel Disease: Pathology, Treatment Options Dec 17
and the Risks of Underdiagnosis
Video CME/Interview, Academy for Continued Healthcare Learning
http://www.freecme.com/courses/2017/3/IDA170_001_ACHL
http://achlcme.org/webcast/ida170-001/index.html
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What is the Estimated Burden of C. difficile in the United States? Nov 17
Live Interview, Contagion Live Infectious Diseases Today
http://www.contagionlive.com/videos/what-is-the-estimated-burden-of-c-difficile-in-the-united-states
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Update in C. difficile Infection May 17
Video CME/Interview, Academy for Continued Healthcare Learning
https://www.achlcme.org/cdi170-01
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C. difficile Spores and More Global Broadcasting Radio Network Apr 17
“Inflammatory Bowel Disease and C. difficile Infection”
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Altering the Cycle of Clostridium difficile infection: Combining Standard of Care and May 16
Emerging Therapies to Prevent Recurrence
Live and Video CME, Academy for Continued Healthcare Learning
http://www.achlcme.org/DDW-Clinical-Commentary
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C. difficile Spores and More Global Broadcasting Radio Network May 16
“Understanding IBS”
https://www.voiceamerica.com/episode/91959/understanding-ibs
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C. Difficile Spores and More Global Broadcasting Radio Network Jan 16
“C. difficile Infections: The What, Where and How”
https://www.voiceamerica.com/episode/89935/c-difficile-infections-the-what-where-and-how
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Original Articles
Feuerstadt P, Hong S, Brandt LJ. “Chronic Rifaximin Use in Cirrhotic Patients is Associated with Decreased Rate of C. Difficile Infection” Dig Dis Sci 2019 (in publication)
Aroniadis OC, Brandt LJ, Oneto C, Feuerstadt P, Sherman A, Wolkoff AW, Kassam Z, Sadovsky RG, Elliott RJ, Budree S, Kim M, Keller MJ. “Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial.” Lancet Gastroenterol Hepatol. 2019 Jul 17.
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Silverman M, Aroniadis OC, Feuerstadt P, Fenster M, Huisman TM, Mansoor MS, Bhutta AQ, Brandt LJ “Older patients are significantly more likely to have colon ischaemia-associated conditions that are chronic and complex” Alimentary Pharmacology and Therapeutics. 2019 Aug;50(3):330.
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Vodusek Z, Feuerstadt P, Brandt LJ. “Review Article: Update in Pharmacological Causes of Colon Ischaemia” Alimentary Pharmacology and Therapeutics. 2019 Jan;49(1):51-63
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Hong S, Feuerstadt P, Brandt LJ. “MELD is the Only Predictor of Short-Term Mortality in Cirrhotic Patients with C. difficile Infection” Dig Liver Dis. 2019 Feb;51(2):275-280
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Fenster M, Feuerstadt P Brandt LJ, Mansoor MS, Huisman T, Aroniadis OA “A Real-World Multicenter Experience on the Pathologic Features of Colon Ischemia and Their Relationship to Symptom Duration, Disease Distribution, and Clinical Outcome” Colorectal Disease 2018 Dec;20(12):1132-1141
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Feuerstadt, P. “Changes in Recommendations for Diagnosis, Disease Severity, and Treatment of C difficile Infection in the 2017 Update to the IDSA/SHEA Clinical Practice Guidelines” Contagion. Jun 2018 Vol 3 No 3. 20-21
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Scott J, Wei D, Scott M, Feuerstadt P. “PEG-3350, Senna and Solid Food Based Bowel Preparation for Colonoscopy Appears Safe, Effective and Well Tolerated” EC Gastro Dig Sys Art. 4.5 (2017): 142-151
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Sharma P, Yadav S, Needham CM, Feuerstadt P. “Sclerosing mesenteritis: a systematic review of 192 cases” Clin J Gastroenterol. 2017 Feb 14
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Brandt LJ, Feuerstadt P. “Beyond Low Flow: How I manage Ischemic Colitis“ American Journal of Gastroenterology. 2016 Dec;111(12):1672-1674 2016 Oct 11
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Pulham N, Feuerstadt P. “Beyond Fellowship: How to Identify the Right Job For You“ Digestive Diseases and Sciences. 2016 Feb; 61(2):355-7
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Feuerstadt P, Brandt LJ “Colon Ischemia: Recent Insights and Advances.“ Current Gastroenterology Reports. 2015 Dec; 17(12):45
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Feuerstadt P, Aroniadis OA, Brandt LJ. “ Acute Mesenteric Ischemia that Accompanies IRCI or Develops in Patients with IRCI Worsens Clinical Outcome of IRCI Alone” Clinical Gastroenterology and Hepatology. 2015 Nov; 13(11):1962-8
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Feuerstadt P. “Translational Medicine: From Bench to Bedside: Clostridium difficile Infection” Clinical and Translational Gastroenterology. 2015 Jun 25
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Brandt LJ, Feuerstadt P, Longstreth G, Boley S. "ACG Clinical Guideline: Epidemiology, Risk Factors, Patterns of Presentation, Diagnosis and Management of Colon Ischemia (CI)” American Journal of Gastroenterology. Jan;110(1):18-44.
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Feuerstadt P, Das R, Brandt LJ. „The Evolution of Urban C. difficile Infection (CDI): CDI in 2009-2011 Has Less Severe Disease and Better Outcomes than CDI in 2006-2008“ American Journal of Gastroenterology. 2014 Aug;109(8):1265-76
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Feuerstadt P, Das R, Brandt LJ. "Location of diverticulosis within the colon influences recurrence and relapse of C. difficile infection" Journal of Clinical Gastroenterology. 2013.May-June;47(5):426-31.
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Brandt, LJ. Feuerstadt, P. “Clostridium difficile: Epidemiology, Transmission and Treatment.” Gastroenterology and Endoscopy News. Sept 2012.
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Feuerstadt, P. Brandt, LJ. “Review Article: C. Difficile: Epidemiology, Diagnosis and Treatment.“ Gastroenterology and Endoscopy News. Sept 2011
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Feuerstadt, P. Brandt LJ. “Colon Ischemia: Recent Insights and Advances.“ Current Gastroenterology Reports. 2010 Oct;12(5):383-90.
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Brandt, LJ. Feuerstadt, P. Blaszka, M. “Anatomic Patterns, Patient Characteristics, and Clinical Outcomes in Ischemic Colitis: A Study of 313 Cases Supported by Histology” American Journal of Gastroenterology. 2010 Oct;105(10):2245-52;. Epub 2010 Jun 8
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Das, R. Feuerstadt, P. Brandt, LJ. “Glucocorticoids are Associated with Increased Risk of Short-Term Mortality in Hospitalized Patients with Clostridium difficile-associated disease (CDAD)” American Journal of Gastroenterology. 2010 Sep;105(9):2040-9. Epub 2010 Apr 13.
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Feuerstadt, P. Bunim, AL. Karlitz, J. Massoumi, H. Garcia, E. Thosani, AJ. Pellecchia, A. Gaglio, P. Reinus, JF. “Effectiveness of Hepatitis C Treatment with Pegylated Interferon and Ribavirin in an Urban Patient Population.” Hepatology. 2010.Apr; 51(4) 1137-43.
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Weitzman, G. Feuerstadt, P. Scherl, E. “Crohn’s and Colitis at the Crossroads Part 2: Redefining the Pyramid: A New Paradigm for 5-ASA Nonresponders.” Gastroenterology and Endoscopy News Special Edition. 2004; Vol 2.
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Feuerstadt, P. Chai, A. Kligfield, P. “Submaximal effort tolerance as a predictor of all-cause mortality in patients undergoing cardiac rehabilitation.” Clin Cardiol. 2007; 30: 234-8.
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Chai, A. Feuerstadt, P. Kligfield, P. “Incremental Improvement in Submaximal Effort Capacity During the Third Month of Cardiac Rehabilitation.” Cardiopulm Rehabilitation, 2005;.25: 1-5.
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Kligfield, P. McCormick, A. Chai, A. Jacobson, A. Feuerstadt, P. Hao, S. "Effect of Age and Sex on Heart Rate Recovery after Submaximal Exercise during Cardiac Rehabilitation", Am J Card, 2003, 92: 600-603.
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Textbook Chapters
Feuerstadt P, Brandt LJ. “Encyclopedia of Gastroenterology” 2nd Edition. Chapter: Colon Ischemia (In Production)
Edited by: Marco Bruno, Francis Chan, Catherine Dube, Emad El-Omar, Alexander Gerbes, Ernst Kuipers, Simon Law, Philip Sherman, Magnus Simren, Christina Surawicz. Elsevier. Netherlands. 2019
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O’Donnell M, Feuerstadt P. Lange: Current Diagnosis and Treatment: Infectious Disease: Chapter 3: The HUMAN GUT Microbiome & Infectious Disease (In Production)
Edited by: Ogbuagu O, Golden M, Villanueva M, Frieldand G. McGraw-Hill. New York, NY. 2018
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Brandt, LJ. Feuerstadt, P. Sleisenger and Fordtran: Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, 11th edition, Chapter 118: Intestinal Ischemia (In Production)
Edited by: Feldman, M. Friedman LS. Brandt, LJ. Elsevier Inc. Philadelphia, PA. 2018
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Brandt, LJ. Feuerstadt, P. Sleisenger and Fordtran: Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, 10th edition, Chapter 118: Intestinal Ischemia
Edited by: Feldman, M. Friedman LS. Brandt, LJ. Elsevier Inc. Philadelphia, PA. 2016
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Brandt, LJ. Feuerstadt, P. Sleisenger and Fordtran: Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, 9th edition, Chapter 114: Intestinal Ischemia
Edited by: Feldman, M. Friedman LS. Brandt, LJ. Elsevier Inc. Philadelphia, PA. 2010
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Feuerstadt, P. Brandt, LJ. Gatroenterological Endoscopy, 2nd edition, Chapter 54: Infectious Diseases of the Intestines
Edited by: Classen, M. Tytgat, NJ. Lightdale, CJ. Elsevier Inc. Philadelphia, PA. 2010. 742-752.
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Online Publications
Feuerstadt, P. Brandt, LJ. Update: “American College of Gastroenterology Patient Information Resource: Intestinal Ischemia” 2019
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Feuerstadt, P. Brandt, LJ. Update: “American College of Gastroenterology Patient Information Resource: Intestinal Ischemia” 2013
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Feuerstadt, P. Brandt, LJ. Clinical Decision Support System Chapter: Update: Ischemic Colitis. Version 2: 2016
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Feuerstadt, P. Brandt, LJ. Clinical Decision Support System Chapter: Ischemic Colitis. Version 1: 2011
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Feuerstadt, P. Brandt, LJ. “American College of Gastroenterology Patient Information Resource: Intestinal Ischemia” 2012
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Feuerstadt, P. Greenwald, D. American College of Physicians: Physicians Information and Education Resource (PIER) Chapter: Ischemic Colitis
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Feuerstadt, P. World Organization of Digestive Endoscopy: Report on Endoscopic Research presented at Digestive Disease Week 2009: ASGE Colon Cancer Screening
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Feuerstadt, P. World Organization of Digestive Endoscopy: Report on Endoscopic Research presented at Digestive Disease Week 2008: GERD: Detection, Management and Follow-Up.
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